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The endocannabinoid system is closely related to the central nervous system and exerts a promising therapeutic potential on it and other systems such as the cardiovascular, mainly through its neuromodulatory, neuroprotective and neuroinflammatory effects. For this reason, when designing new treatments for different relevant pathologies such as hypertension, it is necessary to take into account the side effects that such therapies can cause at the neurological level. Deeping knowledge of each cannabinoid and the molecular mechanisms that can lead to undesired results is necessary. The present review analyzes the psychoactive consequences of anandamide and other similar substances such as other endocannabinoids, phytocannabinoids and synthetic cannabinoids, to assess their little-explored therapeutic potential in clinical investigations. Finally, the major behavioral tests most used until the moment to predict possible changes in the conduct of animals treated with various substances of cannabinoid nature are summarized.

annals of pharmacology and pharmaceutics

Key Aspects to Consider about Beneficial and Harmful Effects on the Central Nervous System by the Endocannabinoid Modulation Linked to New Cardiovascular Therapies