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Irritable bowel syndrome (IBS) is a common chronic functional gastrointestinal impairment, which includes also a variety of psychological and psychiatric comorbidities. The oxidative stress was earlier reported as presenting an important part of the IBS complex pathophysiology. In the present study, we determined the fatty acids profile and thereafter the effects of Camelina sativa Madalina variety cold pressed oil in a zymosan-induced model of IBS. We are showing here some facilitatory effects of the Camelina sativa oil in this context, both on the behavioral and oxidative stress-related actions. Thus, all these results are suggesting some beneficial effects for the present Camelina sativa oil used in this study on behavioural (memory, anxiety, depression and social-related) manifestations and oxidative stress parameters in a zymosan-induced mice model of irritable bowel syndrome. This could be relevant for the connections between the physiological manifestations in IBS and its depressive-like or anxiolytic-like manifestations. In conclusion, Camelina sativa oil exerted facilitatory effects on both the behavioral (short memory, as tested in the Y maze task, anxiety-tested in the elevated plsu maze, depression, as observed in the forced swimming test and social-dominance test) and oxidative stress-related actions (mainly manifested through a general increase of the two main antioxidant enzymes determined here: superoxide dismutase and glutathione peroxidase, as well as a decrease in the lipid peroxidation marker malondialdehyde).

romanian biotechnological letters

Beneficial effects of Camelina sativa oil on behavioural (memory, anxiety, depression and social-related) manifestations and oxidative stress parameters in a mice model of irritable bowel syndrome