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Wound healing is a complex process that still needs improving. The keratinocyte differentiation « in vitro » model together with the evaluation of cell cycle sequentiation and collagen synthesis offer a correlative panel for a background screening of the main events that sustain the skin renewal. The experimental design was based on cytotoxicity and efficacy evaluations of keratinocytes (HaCaT cell line) and fibroblasts (HS27 cell line), through flow cytometry, microscopy and specto-photometric techniques. Our current study shows important effects on the aforementioned processes for two vegetal extracts that we used: Camelina sativa oil (CAM), a plant which was less explored until now, but with a clear potential for some therapeutical effects and the Grape pomace (TES), a waste from winery industry, used mainly on an empirical base before. Camelina oil, through its composition rich on fatty acids, accelerates the dermoepidermal “de novo” synthesis, stimulating the keratinocytes differentiation and turn-over and also fibroblasts cellular division and collagen synthesis. The previously described antioxidant actions of TES extract are also mainly expressed through the over-expression of involucrine, transglutaminase-1 and cytokeratine 5/14, as key events of epidermal layers growth and mithotic phases amplification in keratinocytes and fibroblasts synthesis. All of these effects are suggesting the regenerative and scare healing potential of both extracts, with direct possible applications in pharmaceutical and cosmetic industry.

Regenerative and scare healing potential of active compounds from Camelina sativa oil and grape pomace