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Effect of melatonin implanted in the femoral region on the diurnal rhythmic patterns of the peripheral leukocyte counts was studied in chicks. The diurnal rhythmic patterns of lymphocyte count and monocyte count, which shows two peaks of counts in a day, respectively, disappeared by the continuous melatonin administration. In the granulocyte count, rhythmic pattern was altered by the melatonin treatment. The results suggest that melatonin is involved in rhythm formation of the peripheral blood leukocyte numbers in chicks by acting upon some target sites which have been assumed to be concerned with the rhythm formation of peripheral blood leukocyte count.

Effect of Continuous Melatonin Administration on the Diurnal Rhythms of the Peripheral Blood Leukocyte Counts in Chicks