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Recently, studies on the immunobiological effects of dietary lactic acid bacteria and their fermented dairy products have progressed via short-term studies on several animal systems4). Many researchers have suggested that dietary lactic acid bacteria or their products can augment immune responses5). Our previous studies showed that slimeforming Lactococcus lactis ssp. cremoris KVS20 (L. lactis ssp. cremoris KVS20) stimulates the cytotoxic activity of macrophages6,7) and the mitogenic activity of murine lymphocytes8,9). In addition, we demonstrated that a phosphopolysaccharide isolated from slime products produced by L. lactis ssp. cremoris KVS20 induces substantial activity in murine spleen cells as a B-cell mitogen9). However, it is still uncertain whether the substance exerts similar activity on lymphocytes from other kind of animals. This study was undertaken to evaluate the mitogenic activity of the phospho-

Comparative Activity of B-Cell Mitogen, a Phosphopolysaccharide, Produced by L. lactis ssp. cremoris on Various Lymphocytes