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It was previously shown that the clearance rate of bromsulfalein (BSP) by the liver of sheep decreased when methemoglobin content increased in blood of sheep1). The relationship between BSP residue value in serum and methemoglobin content in blood in the previous examination was described by a single equation. However, though the clearance rate of BSP seemed to be the most useful indicator for showing various damages of the liver function2), the previous examination failed to show by which pathway the liver damages occurred, when hemoglobin was converted to methemoglobin after administration of nitrite into the rumen of sheep. The present investigation was undertaken to see the liver function of sheep of methemoglobinemia by determining various serum constituents, which were known to have relation with protein, carbohydrate and fat metabolism, enzymic activities and biligenetic function of the liver.

Effects of Methemoglobin Formation in Blood on Some Serum Constituents Related to the Liver Function of Sheep