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Human adenovirus (HAdVs) are responsible for about 65-90% of viral conjunctivitis. Understandings of HAdVs bring promises in prevention, treatments, and biological preparations. However, thorough researches on structural proteins of HAdVs are still limited in Vietnam. In this study, we have sequenced the entire coding gene of protein hexon from HAdV-3 causing conjunctivitis in Vietnam and compared with the reference sequence in NCBI database. We detected 42 DNA variants, of which, 11 resulted in amino acid substitutions. Simulation of HAdV3 hexon structure showed that all 11 substitutions located in crucial positions. This result revealed high risks from hexon gene variants of HAdV-3 enhancing its life span, virulence, and ability to avoid the host immune system.

Sequencing Coding Region and in Silico Structural Analysis of Protein Hexon of HAdV-3 Causing Conjunctivitis in Vietnam