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The compound ent-7β-hydroxy-15-oxo kaur-16-en-18-yl acetat (CT1) is the major constituent and found uniquely in the medicinal plant Croton tonkinensis Gagnep. This compound was also found to have numerous pharmaceutical activities, therefore, it should be considered as a main bioactive constituent of this plant material. However, the Vietnamese Pharmacopoeia IV (2009) postulates the qualitative analysis of this herb by thin layer chromatography (TLC) using standard sample of herbal Crotonis tonkinensis. In this study, we indicate that the material of this herb could be qualitative analysed by TLC and HPLC by using CT1 as a reference compound. The study also develops a method for quantitative analysis of the compound CT1 in the medicinal materials Crotonis tonkinensis by HPLC (column C18; UV detector at 233 nm; solvent acetonitril-water 65:35). The contents of CT1 in some Crotonis tonkinensis samples collected in northern Vietnam were determined to be 0,51–1,27 % in leaves, 0,32–0,46 % in green stems and 0,14–0,18 % in old stems, indicating that leaves contain highest amount of CT1. The results of this study suggest that the compound CT1 should be used as a reference compound for qualitative and quantitative analysis of the material herb Crotonis tonkinensis in Vietnamese Pharmacopoeia. Keywords Crotonis tonkinensis, ent-7β-hydroxy-15-oxo kaur-16-en-18-yl acetat (CT1), reference compound, qualitative and quantitative analysis References [1] Đỗ Huy Bich va cộng sự (2004), Cây thuốc va động vật lam thuốc ở Việt Nam, NXB Khoa học va Kỹ thuật, Ha Nội, tập II, tr. 87-89.[2] Vo Văn Chi (1997), Từ điển cây thuốc Việt Nam, NXB Trẻ, TP Hồ Chi Minh, tr. 622-623.[3] Đỗ Tất Lợi (2001), Cac cây thuốc va vị thuốc Việt Nam, NXB Y học, tr. 826.[4] Phương Thiện Thương va cong sư (2011), Tổng quan nghien cứu về thanh phần hoa học va tac dụng sinh học của cây khổ sâm cho la, Tạp chi Dược liệu 16 (1+2), 9-19.[5] Thuong P. T. et al. (2014), ent-Kaurane diterpenoids from Croton tonkinensis induce apoptosis in colorectal cancer cells through the phosphorylation of JNK mediated by reactive oxygen species and dual-specificity JNK kinase MKK4, Anti-cancer Agents in Medicinal Chemistry 14, 1051-1061.[6] Kuo P.C. et al. (2007), Crotonkinins A and B and related diterpenoids from Croton tonkinensis as anti-inflammatory and antitumor agents, J. Nat. Prod. 70, 1906-1909.[7] Kou P.C. et al. (2013), Anti-inflammatory diterpenoids from Croton tonkinensis, J. Nat. Prod. 76, 230-236.[8] Nguyen Văn Thoan va cong sư (2016), Tac dụng chống viem cấp va mạn của hợp chất ent-7-hydroxy-15-oxokaur-16-en-18-yl acetate từ khổ sâm cho la, Tap chi Khoa hoc ĐHQGHN, Khoa hoc Y Dươc 32 (2), 26-31.[9] Dao T.T. et al. (2010), Sirt1 inhibitory diterpenoids from the Vietnamese medicinal plant Croton tonkinensis, Planta Med. 76, 1011-1014.[10] Tuan D.T. et al. (2011), ent-Kaurane diterpenoids from Croton tonkinensis stimulate osteoblast differentiation, J. Nat. Prod. 74, 2526-2531.[11] Bộ Y tế (2009), Dược điển Việt Nam IV, NXB Y học, tr. 802-803.[12] Trần Thu Hiền va cộng sự (2016), Nghien cứu chiết xuất, phân lập hợp chất diterpenoid chinh từ cây khổ sâm cho la (Croton tonkinensis Gagnep.), Tạp chi Dược học 56 (483), 60-62.

tạp chí khoa học đại học quốc gia hà nội: khoa học y dược (vnu journal of science: medical and pharmaceutical sciences)

Xây dựng phương pháp định tính, định lượng hoạt chất ent-7-hydroxy-15-oxokaur-16-en-18-yl acetate trong dược liệu khổ sâm cho lá (Croton tonkinensis Gagnep.)