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Safety evaluation was made on Biological canal paste (BCP), one of newly developed endodontic pastes used for Ultrasonic Bio-Mechanical Obturation Systern. BCP was characteristic of a high content of thymol to show extreme antimicrobic action, The basic biological tests on cytotoxicity, systemic toxicity, mutagenicity and dermal sensitization were carried out in this study, On potency of cell growth inhibition in vitro, BCP was as same as Canals-Nas and much less than Canals'ge, As neither death nor toxic $yndrome in mice was found from administration of BCP in oral maximal dose of 1,Omg/kg, it was estimated that LDso of BCP should be not less than the value of 'slightly toxic' classified by Deichmann. BCP showed negative results in mutagenicity examined by Ames test, and also in delayed type allergenicity by Adjuvant and patch test, From the above it was suggested that BCP was possibly safe so far as it was used properly for dental therapy.

A Study on a Root Canal Filling, Containing Thymol in High Concentration