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It has been well known that intracellular increase in CaTinduced by massive release of excitatory amino acid and by increased phospholipid metabolism during and after ischemia that plays an important role in brain damage. Furthermore, recent studies revealed that mild hypothermia (only 2-5 OC reduction of brain temperature below normothermia) provided protective effect, though the mechanism of this effect is still unclear, The present study was designed to gain further insight into the mechanism for neuroprotective effect of mild

Hypothermia Prevents Neuronal Degeneration in Rat Progressive Brain Ischemiaia