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Inflamed gingiva of hurnan contains immunoglobulins directed to several oral microorganismsi-4) . The finding is consistent with the following hypothesis : as the inflammatory reaction of gingiva is regarded as the first step of the periodontitis5) . Microorganisms invaded to gingiva encounter specific antibodies. Resulting immunocomplex may cause the activation of the classical complement pathway, which develops the inflammation followed by the chronic periodontitis. In the healthy human serum or saliva natural occurring antibodies to Streptococcus mutans, Streptococcus sanguis, Streptocoecus mitis, Lactobacillus acidophilus6), Lepto-

Localization of Antibodies to Oral Microorganisms in Oral Mucosal and Submucosal Tissues of Healthy Rat