Open AccessNLRP3 Inflammasome Mediated Production of Th1/Th17 Cytokines in Response to Inflammatory Stimulants in Innate Immune Cells
Author(s) -
K Amrithavarshini,
Akshaya Keerthi SAIKUMAR,
Manigandan Venkatesan,
Vishnu Raghuram,
Shahana Parveen,
V. Sugitharini,
Rohit Saluja,
E. Berla Thangam
Publication year - 2019
Publication title -
turkish journal of immunology
Language(s) - English
Resource type - Journals
ISSN - 2147-8325
DOI - 10.25002/tji.2019.1019
Subject(s) - innate immune system , inflammasome , inflammatory response , immunology , immune system , inflammation , medicine , biology
Monocytes play a major role in eliciting the immune response against infection. Also mast cells are found to play a critical role in mediating inflammatory immune response not only to allergic reaction but also to infection by inducing the production of inflammatory cytokines such as IL-1β, IL-6, IL-18 and IL-17. This study aims to investigate nod like receptor protein 3 (NLRP3) mediated production of Th1/Th17 cytokines in monocytes and mast cells.
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