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Objective: In  diabetes  mellitus (DM) type 2, there  is  a  very  high  risk  of developing cardiovascular  (CV) events.  We aimed to study the total CV risk of the indigenous people of  Kyrgyzstan with  impaired carbohydrate metabolism (DM type 2 and impaired glucose tolerance, IGT), depending on  the region of residence (low and high altitudes), and to  develop targeted preventive measures. Methods: Overall, 248 families (992 people) in the Naryn (high-altitude) (study group) and 260 families (1041 people) in the Chui region (low-altitude) (control group) were surveyed and  363 people with DM type 2 and IGT were identified, of which: 138 people in the study group and 225 people in the control group. Results: In patients with DM type 2 and IGT, moderate CV risk was found in the low-altitude and high-altitude in men and women aged 46–65 years, the  leading risk factor in men is BMI>25 kg/m2; in women, hypertension (HT)  and hypercholesterolemia. A high risk of  CV  complications was detected only in the low-altitude in men aged 46–65 years, the leading risk factor is HT. High and very high risk of CV complications  are rarely found both in the low-altitude and in the high-altitude. Conclusion: During stratification of total CV risk, 363 people with carbohydrate metabolism disorders (DM type 2 and IGT) of  2033 native population living in 2  regions  of Kyrgyzstan revealed features of the total CV risk: BMI>25kg/m2 for men of  high- altitude  and  low-altitude,  HT  and hypercholesterolemia  for  women of high-altitude, and for men, low-altitude only HT. Both in the high-altitude and in the low-altitude, low and moderate CV risk are predominantly expressed, and high and very high CV risk are rare.

heart, vessels and transplantation

Total cardiovascular risk among native population of Kyrgyzstan with diabetes mellitus type 2 and impaired glucose tolerance in high- and low-altitude regions