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Ethambutol can cause a well-described, dose-related optic neuropathy. We performed a retrospective analysis of patients with ethambutol optic neuropathy to evaluate visual function and Visual Evoked Potentials (VEP). We found that vision decline was more severe if ethambutol cessation took longer than 4 weeks from initial visual decline, but that patients on ethambutol for greater than 8 months actually presented with better vision than patients on it for less than 8 months. VEP amplitudes were reduced in all patients, but latencies were normal. These findings suggest that it is important to monitor vision in the first 8 months of treatment. Although it is important to stop ethambutol as soon as toxicity is detected, most patients will recover some vision upon cessation.

Ethambutol Optic Neuropathy Visual Function And Visual Evoked Potentials