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The objective of the study is to determine sufficient Thrombogenic Risk (TR) factors of post-operative Venous Thromboembolic Complications (VTEC) development on the background of modern thromboprophylaxis including non-pharmacological and pharmacological implications. Materials and methods The observation data of 351 patients who underwent primary total Hip Replacement (HR) are presented in the article. The interview of patients and the study of medical documentation were carried out. Some laboratory (as well as genetic) analysis methods were used to reveal the potential TR factors. Results Six TR factors out of 26 were determined to increase the possibility of VTEC occurrence significantly. They are type 2 diabetes mellitus (odd ratio OR 5.6; 95% confidence interval CI 1.8-17.0), female sex (OR 4.6; CI 1.5-13.6), low level of physical activity (OR 4.4; CI 1.7-11.1), age over 60 (OR 4.3; CI 1.8-10.6), increased level of D-dimers before operation (OR 3.5; CI 1.4-8.9) and varicose disease of the lower extremities (OR 3.4; CI 1.5-7.7). Conclusion Revealed TR factors allow for determining the group at high risk of VTEC after HR and developing approaches to the individual thromboprophylaxis among these patients.

Prognosis of Venous Thromboembolic Complications after Hip Replacement on the Background of Modern Thromboprophylaxis