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In the developed and developing world nutritional interventions have become essential to prevent global Non Alcoholic Fatty Liver Disease (NAFLD) and to maintain the metabolism of glucose, fatty acids, cholesterol, amyloid beta, bile acids and xenobiotics. The World Health Organization (WHO) has reported that cardiovascular disease is the most prevalent global chronic disease that may be connected to NAFLD and the alarming death rate in various communities. Caffeine (appetite suppressant) may improve the adipose tissue-liver cross talk with the prevention of NAFLD in obese and Type 2 diabetic populations. Overeating may accelerate chronic diseases with repression of anti-aging genes linked to NAFLD and delayed caffeine clearance linked to the induction of Type 3 diabetes in global populations. Nutritional interventions to reverse NAFLD in the developing world are associated with accelerated caffeine clearance rates with prevention of caffeine induced mitochondrial apoptosis that is linked to early neuron loss and the development of Type 3 diabetes in these populations.

Nutrition Therapy Regulates Caffeine Metabolism with Relevance to NAFLD and Induction of Type 3 Diabetes