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Diyushengbai Tablet (DST), a Chinese patent medicine made from raw material of Sanguisorba officinalis L., has been used to cure leukopenia caused by various radiotherapy and chemotherapy in clinic for more than 20 years, which is the major side effect of stopping cancer treatment, and shown significant efficacy [1-3]. Ziyuglycoside I (ZgI), the main saponin from Sanguisorba officinalis L., has been proved to be the primarily active ingredient of leukogenic action of DST [4]. Previous studies have shown that ZgI can remarkably increase the levels of White Blood Cells (WBCs) and platelets in leukopenia mice induced by Cyclophosphamide (CY) and can also relieve its bone marrow depression [5-7].

Comparative Plasma Pharmacokinetics of Ziyuglycoside I from Sanguisorba Officinalis L. between Leukopenia and Normal Rats via UHPLC-MS/MS