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Background: Stem bark of Tieghemella heckelii (Sapotaceae) used as traditional medicine for its therapeutic effect on infectious diseases in Ivory Coast, was tested against imipenem-resistant bacteria for efficacy assessment. Methods: Six extracts (hexane, chloroform, ethyl acetate, ethanol, methanol and sterile distilled water) were prepared and tested on Imipenem-Resistant Pseudomonas aeruginosa (IRPA), using broth microdilution for activity evaluation. From this experiment, the Minimum Inhibitory Concentrations (MICs) and Minimum Bactericidal Concentrations (MBCs) of the plant extracts were determined in 96-well micro-plates in order to search for both bacteriostatic and bactericidal effects. Thereafter, data analysis was performed using GraphPad Prism 5 software (One-way ANOVA, Bartlett test for equal variance and Turkey Multiple Comparison test). The results were then presented as Mean ± SD for experiment repeated three times. Results: Four extracts (ethyl acetate, methanol, ethanol and sterile distilled water) showed credible potency, with strong, significant and moderate growth inhibition of the IRPA tested. The MIC values varied depending on microbial phenotype, and were within the range of 0.048 mg/mL to 12.5 mg/mL. As for the MBC values, also associated to bacteria strain type, they demonstrated both bacteriostatic and bactericidal effects of the active extracts towards Imipenem-resistant P. aeruginosa. Conclusion: Stem bark extracts of Tieghemella heckelii showed an antibacterial effect towards imipenem-resistant P. aeruginosa. They could therefore be used to deplete the prevalence rate of the named resistant strains.

hsoa journal of alternative, complementary and integrative medicine

Stem Bark’s Extracts of Tieghemella heckelii (Sapotaceae) Against Imipenem-Resistant Pseudomonas aeruginosa: Identification of a Prospective Antibacterial Agent