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Topicality. Smoking continues to be one of the most important medical and social problems of modern society. The detrimental effect of smoking is associated with the presence of a large number of tobacco carcinogens and toxic substances. The widespread use of nitrates and nitrites in industry, agriculture led to pollution inorganic oxides of nitrogen and their chronic toxic effects on the human body. The study of combined influence of several xenobiotics in the body is appropriate and relevant. The aim of the work – to investigate the performance of oxidative modification of proteins and activity of bioenergetic processes in rats of different ages for the defeat of sodium nitrite in 45 days on the background of toxicity by tobacco smoke. Materials and methods. Experiments were conducted on rats of different ages, who for 45 days had been exposed to tobacco smoke. For 24 hours before the end of the experiment the animals were injected with sodium nitrite at a dose of 45 mg/kg of body weight, another group of sodium nitrite was administered 72 hours before euthanasia. Rats were taken out of the experiment under thiopental anesthesia. Serum and organs of animals were tested for 2,4-dynitrofenilhidrazone in organs – the activity of succinate dehydrogenase and cytochrome oxidase. Results and discussion. On an experiment on rats of different ages we found that under the conditions of sodium nitrite poisoning on the background of 45 day toxicity by tobacco smoke there is activation of oxidative modification of proteins, as indicated by the increase of 2,4 dynitrofenilhidrazone serum and organs of animals. At this time we marked an inhibition of mitochondrial enzymes, indicating abuse bioenergetic processes in the body. Conclusions. We found that the most pronounced changes in the processes of oxidative modification of proteins and bioenergy provision in the body of sodium nitrite affected against the background of tobacco intoxication were observed in immature and senile rats.

Proteins oxidative modification and mitochondrial enzymes activity in rats of different ages under affection by sodium nitrites and tobacco smoke