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The article considers the pathomorphological studies of the effect of vaginal suppositories “Melanizol” on the irritative vaginitis caused by a mixture of turpentine and dimethylsulfoxide in rats. Vaginal suppositories “Melanizol” showed a therapeutic effect on the vaginitis, which manifested by preventive the occurrence of necrotic-inflammatory lesions, and promoted the healing of defects in mucosal and submucosal layer of the vaginal wall. Low positive therapeutic effect of suppositories “Gravagin” on the state of the vaginal wall of female rats on the model of experimental vaginitis has been proven. Sufficiently large foci of destruction of the vaginal wall, foci of inflammation, edema of collagen fibers of rats vaginal wall of this group was present. Vaginal suppositories “Melanizol” are perspective for using as a drug for the treatment of nonspecific vaginitis with destructive reaction and inflammation.

Pathomorphological research of vaginal suppositories "melanizol" against irritative vaginitis