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The physical, physicochemical and pharmacotechnological properties of active pharmaceutical ingredients and their mixtures with the excipients of “Api-Immuno-Vit” capsules with the immunomodulatory action based on bee bread and powdered honey have been studied. The results of the analysis of the resulting masses for encapsulation of the mixtures with active substances indicate the necessity of introduction of antifriction substances and humidity regulators into the composition of the drug being developed and allow determining the rational composition and the quantitative content of excipients. By the pharmacotechnological studies conducted the expediency of obtaining granules by the wet granulation method of the mass for encapsulation using the alcohol-water mixture in the concentration of 80% as a moisturizer has been determined.

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Development of the composition and technology of the capsulated drug based on bee bread and honey powder. Report 2. The study of pharmacotechnological properties of the mixtures of active pharmaceutical ingredients with excipients of “Api-Immuno-Vit” caps