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Based on the results of the microbiological research the necessity of introduction of a preservative into the gel with essential oils developed for treating diseases of the upper respiratory tract has been proven. The microbiological research has been conducted according to the conventional method of the SPhU with the gel samples, in which the following preservatives were added: sodium benzoate, methylparaben, the complex preservative “Germaben”, the complex of sodium benzoate with Nipagin in the ratio of 0.5:0.1. It has been found that all gel samples under study meet of the SPhU requirements for microbiological purity (according to the criterion “A” and “В”). While conducting the comparative analysis it has been determined that addition of the preservative complex of sodium benzoate with Nipagin in the ratio of 0.5:0.1 is the most effective. At present there is a tendency to use topical drugs with a high aqueous phase content (creams water/oils, gels). However, these drugs are a favourable environment for microbial growth (cultures of S. aureus, Ps. aeruginosa) or spoiling of finished products (culture of mold fungi, yeast fungi of the Candida genus) [3, 5, 7]. As a result of the comprehensive research the composition of a gel with essential oils for treating diseases of the upper respiratory tract have been developed [6]. Due to the fact that the gel developed should be stable, including its microbiological purity value, at least for 2 years, it is necessary to study the microbiological purity of this gel and select the optimal preservative and its desired concentration [4, 5, 6]. It is known that when selecting a preservative the attention should be paid to the therapeutic effect of the drug, its area of application, interactability with other ingredients of the formulation, and its solubility. Based on the literature search in order to select an effective preservative (or their combination), which is able to provide the quality and safety of the gel with essential oils developed, we studied the antimicrobial activity of the experimental samples of gels with different preservatives. The following preservatives were selected for the studies: sodium benzoate, methylparaben (Nipagin, methyl ether of n-4-hydroxybenzoic acid), and the complex of sodium benzoate with Nipagin. The complex preservative “Germaben” was also studied, it included diazolidinyl urea, methylparaben, and propylparaben in propylene glycol [2, 8, 10].

Substantiation for selecting a preservative when developing the gel with essential oils for treating diseases of the upper respiratory tract