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thiazole cycle at 7.62-7.57 ppm, for 1-alkyl-5-methyl-6-(2-methyl-1,3-thiazol-4-yl)-3-phenylthieno[2,3-d] pyrimidine-2,4(1H,3H)-diones the signals of the methylene group protons are observed in the range of 5.13-5.21 ppm for benzyl substituted derivatives and 4.78-4.82 ppm for the compounds with the acetamide fragment; the last ones also contain the sharp signal of NH proton in the range of 9.6810.41 ppm. 5-Methyl-6-(2-methyl-1,3-thiazol-4-yl)-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione showed the antimicrobial activity against Staphylococcus aureus higher than the reference drugs Metronidazole and Streptomycin, it also appeared to be moderately active against Pseudomonas aeruginosa and Candida albicans fungi. The antimicrobial activity of 1-alkyl-5-methyl-6-(2-methyl1,3-thiazol-4-yl)-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-diones is inferior to the activity of the compound with the hydrogen atom in position 1; the highest activity has been determined for the derivative with 4-methylbenzyl substituent in position 1, which inhibits the growth of Staphylococcus aureus and Candida albicans. In the last years the interest to derivatives of 6-hetarylthieno[2,3-d]pyrimidines has grown. They were reported as adenosine А2А receptors antagonists [8], as the compounds with antioxidant [10] activity and acetyl-CoA carboxylase (АСС) inhibitors [7]. Some compounds of the similar structure are potential anti-viral agents [9]. Our last investigations also confirm the expediency of searching novel antimicrobial agents in the range of thieno [2,3-d]pyrimidine derivatives modified in position 6 with the aromatic heterocyclic substituents [2, 3, 4, 12]. We have also found that in some cases the presence of the electron-withdrawing substituent in position 6 of thieno [2,3-d]pyrimidine together with alkylation of the nitrogen atom in position 1 promotes the antimicrobial activity of the compounds [11].

Synthesis and the antimicrobial activity of 5-methyl-6-(2-methyl-1,3-thiazol-4-yl)-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-diones