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The current literary sources have been analysed. The choice of the substance as the main active ingredient for preparing a drug with the immunomodulatory action in the form of granules has been substantiated. The study of physico-chemical and pharmaco-technological properties of granules with bee bread has been conducted. Based on the SPhU method the experimental research in studying fluidity, the value of the angle of repose, bulk volume before and after settling, directly settling qualities, moisture absorption and moisture content of granulated and common bee bread has been performed. Dependence of moisture absorption of the drug samples in the form of granules on time has been studied; disintegration of the test samples of the drug with the immunomodulatory action based on bee bread granules has been investigated. With the help of the combination of active substances the indicators of fluidity have been maximally improved; it is considerably necessary for further development of the drug. It has been shown how the excipients and the method of granulation affect the technological properties and quality of the drug. Superiority of granulated bee bread over common bee bread has been studied and experimentally proven by all physico-chemical parameters and technological properties. The optimal compositions for obtaining an immunomodulator have been analysed and selected. The samples of granules with bee bread have been obtained and studied. With the help of physico-chemical and pharmaco-technological investigations the choice of one sample and the composition of the drug in the form of granules for use as an immunomodulator has been scientifically substantiated. Immunity is the most important factor for existence of all living beings. The essence of its functioning is to identify, process and remove a foreign body from the organism. This process of host defense occurs both by the natural way (i.e., by means of innate immunity) and artificial ly (by means of acquired immunity). Both types of immunity always work in pairs, complementing each other. Thus, innate immunity performs its work at the stage of disease (i.e., the initial stage) and at the stage of recovery (the final stage), and acquired immunity performs the intermediate function, it identifies and remembers the virus passed into the body in order the organism to be ready for reinfection in future. The main organs in the complex mechanism of the immune system are lymph nodes, bone marrow, spleen, thymus gland. They are the first to react to changes in the defence system of immunity. Moreover, all unfavourable factors affecting the immune system are reflect ed exactly on these organs. Such factors include bad

Development of the composition of the drug with the immunomodulatory action in the form of granules based on bee bread