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When developing the technology of a dry extract of hop cones as an active pharmaceutical ingredient with the estrogen-like action the key factors that can affect the quality of the finished product have been investigated. Taking into account that hop prenyl flavonoids are relatively unstable compounds and under certain thermodynamic conditions are prone to transformation the influence of the temperature parameters such as evaporation and drying of the hop liquid extract on the content of xanthohumol (X), isoxanthohumol (IX), 8-prenylnaringenin (8-PN) and 6-prenylnaringenin (6-PN) in the dry extract has been researched. The objects of the research were the samples of the hop liquid extract after extraction of the raw material and the dry extract after evaporation and drying. The extraction of hop cones has been carried out by the two-step filtration method extraction with the pretreatment of the raw material with steam. At the first step the hop raw material was extracted with n-hexane with the subsequent extraction of the extraction cake with water-alcohol solvent at the second step. The aqueous-ethanol extract was evaporated and dried in vacuum to prevent possible destruction of prenyl flavonoids. The quantitative content of xanthohumol, isoxanthohumol, 8-prenylnaringenin and 6-prenylnaringenin has been determined by HPLC in the samples of liquid and dry extracts. It has been found that sparing conditions of evaporation and drying used has led to decreasing the quantitative content of X, IX, 8-PN and 6-PN in the dry extract compared with the content of these compounds in the water-alcohol liquid extract in the range of 14, 16, 8, 14%, respectively.

The study of dependence of the prenyl flavonoids content in the hop dry extract on temperature parameters of its obtaining