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On the basis of experimental studies the authors have demonstrated that a topical issue of the pharmaceutical science today is development of the rational therapeutic dosage forms based on standardized biologically active substances of bee products that have specific chemical and pharmacological properties for new domestic, natural, highly effective drugs for prevention and treatment of ulcer diseases of the human gastroduodenal area. The pharmaceutical market of drugs with the antiulcer activity of different dosage forms has been analyzed. It has been found that dosage forms produced in a small range are economically and socially efficient for further development of a completely new drug based on bee products. Today science has proven that encapsulated dosage forms are promising. This dosage form is a cost effective, and allows to encapsulate various drugs from substances in the solid state to liquid and pasty ingredients. Research in recent years has confirmed that the choice of a rational dosage form of drugs in combination with excipients provide the optimal pharmacological effect of drugs under development, which production is possible both in industrial and pharmacy conditions. The study of natural medicinal resources of our country in order to seek new sources of biologically active substances and creation of national drugs on their basis is a topical issue of pharmacy. Continuing the experiments with the results presented in the publication [2] the aim of this study was to develop an optimal composition and the rational technology of a solid dosage form – capsules for treating ulcerative gastroduodenal diseases. As for this problem, bee products (pollen, propolis, honey, bee venom, royal jelly, bee bread) are of particular interest as sources of the raw material. Volumes of their procurement in Ukraine (the data of 1995) are: propolis – 20 tons, pollen – 100 tons, bee venom – 200 kg, honey – 40,000-60,000 tons, royal jelly – 100 kg and wax – 800 tons. This amount is sufficient for industrial production of drugs, besides it is a domestic raw material that is always at hand, and its transport costs are negligible. Since ancient times bee products are widely used in folk medicine to treat various diseases [19]. Fundamental research of domestic and foreign scientists has proven their high biological value and versatile pharmacological activity (anti-inflammatory, antimicrobial, anesthetic, antioxidant, immune-stimulating, antiradiation, antiulcer, hepatoprotective, etc.). Moreover, they are practically

Methodology of creating an encapsulated dosage form with bee products. Report II