English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

On the model of collagen-induced arthritis in rats the anti-inflammatory properties of the composition containing the combination of doxycycline hydrochloride and glucosamine hydrochloride have been studied in comparison with its active monocomponents – doxycycline, glucosamine hydrochloride. According to the results of the experimental studies it has been proven that the composition containing the combination of doxycycline hydrochloride and glucosamine hydrochloride have a strong beneficial effect on the metabolism of the cartilage and bone tissue against the background of the autoimmune arthritis development and leads to inhibition of autoimmune processes in the connective tissue of animals. The normalization of the functional state of the joints and the clinical and biochemical parameters has been observed. By the degree of the pharmacological effect on the most parameters studied the combination exceeds the reference objects – the substance of doxycycline hydrochloride and glucosamine hydrochloride. The composition containing the combination of doxycycline hydrochloride and glucosamine hydrochloride is a promising corrector of the inflammatory and destructive joint diseases with the autoimmune component, and can be recommended for use in the complex therapy of patients with immuno-inflammatory and inflammatory-destructive diseases of joints.

klìnìčna farmacìâ

The effect of the compositioin containing the combination of doxycycline hydrochloride and glucosamine hydrochloride on the structural and metabolite indicators in rats with collagen-induced arthritis