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Polymeric PS nano-drugs (chlorin e6 conjugate with acetylated hyaluronic acid and chlorin e6 conjugate with acetylated chondroitin sulfate; NPSs) were synthesized via carbodiimide reaction as nano-scale drugs for long term photodynamic therapy. The samples were self-assembled with average sizes below 200 nm. Their self-photoquenching properties in the aqueous phase were observed, while fluorescence intensity was strongly correlated with the amount of Ce6 in the organic solvent dimethyl sulfoxide (DMSO). In vitro phototoxicities of the NPSs are similar with free Ce6 measured by 3-[4,5-dimethylthiazol-2yl]-2,5-diphenyltetrazolium bromide (MTT) assay. The self-quenching effect and fluorescence recovery of NPSs were determined using KODAK imagestation. Compared with free Ce6, NPSs were retained at the tumor region due to their self-aggregate property. Also, in vivo tumor suppression effect was maintained until 10 days. These results suggest that the NPSs can give new idea for long term therapy in the clinical application of photodynamic therapy.

Polymeric Photosensitizer Nano-drugs for Long Term Therapeutic Effect: in vitro and in vivo Phototoxicity against Human Colon Cancer (HCT-116)