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Abnormal production of and response to interleukin-2 in peripheral blood and synovial fluid lymphocytes in rheumatoid arthritis The cell surface phenotypes and interleukin-2 related function were studied employing lymphocytes from peripheral blood(PB)and synovial fluid(SF)of patients with rheumatoid arthritis(RA). The numbers of IL-2R positive and Ia positive lymphocytes from peripheral blood of patients with RA were increased when compared to normal blood. Con A activated lymphocytes both from PB and SF in patients with RA produced decreased IL-2. In contrast, unstimulated PB lymphocytes from RA patients, who had active disease and whose disease duration was less than 3 years, showed increased proliferation response to IL-2(P<0.01). RA SF lymphocytes showed increased response to IL-2 than PB lymphocytes with RA(P<0.01). In synovial fluid, numbers of 2H4+CD4 cell were decreased. Those abnormalities in T lymphocytes from RA patients appeared to play an important role in pathogenesis of RA. Jun Okada• Sadao Kashiwazaki* *Department of Internal Medicine, School of Medicine Kitasato University key words: interleukin 2, rheumatoid arthritis, synovial fluid

Abnormal production of and response to interleukin-2 in peripheral blood and synovial fluid lymphocytes in rheumatoid arthritis.