English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Group 2 innate lymphoid cells (ILC2s) mediate rapid immune responses against microbial infection by secreting large amounts of T helper type 2 (Th2) cytokines. Exposure to environmental stimuli including parasites, viruses, bacteria and protease allergens, damages epithelial cells, resulting in the secretion of thymic stromal lymphopoietin (TSLP), interleukin (IL)-25 and IL-33. These cytokines are potent inducers of Th2 cytokines from ILC2s. ILC2-produced Th2 cytokines result in the recruitment of eosinophils, mast cells and basophils to inflammatory sites, thus initiating type 2 innate immunity. Immunological information from the innate immunity is then received by Th2 cells, leading to pathogen-specific antibody production and persistent eosinophil activation. Among Th2 cytokines, IL-5 acts particularly on eosinophil regulation. In cooperation with Th2 cells, IL-5-producing ILC2s regulate eosinophil biology in the steady state and innate immunity. Rec.1/20/2014, Acc.2/16/2014, pp140-148

Roles of IL-5-producing group 2 innate lymphoid cells in eosinophil regulation