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Over the last few years, the mesenchymal stromal compartment of the bone marrow has regained interest. The main reason for this resurgence is the recognition of their immunomodulatory properties and their prominent role in the maintenance and regulation of hematopoiesis. This has simultaneously prompted preclinical and clinical studies trying to take advantage of these properties and, at the same time, basic studies that have tried to dissect the bone marrow stromal compartment and the specific functions that different stromal cells have in the regulation of hematopoiesis and immunity. In this minireview we will summarize our contributions to the functions of mesenchymal stem cells in regulating hematopoietic stem cells. By putting them in a broader context, we will discuss the emerging role of mesenchymal stem cells as key integrators of neuro-endocrine signals, able to couple whole-organism demands to fine-tuned responses in remote stem cell niches. Rec.12/4/2012, Acc.12/10/2012, pp38-47

Network anatomy and in vivo physiology of mesenchymal stem and stromal cells