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We reported previously the establishment and platelet aggregating activity of human lung adenocarcinoma cell line KUM·LK-2 which produce spontaneous metastasis in nude mouse. Platelet aggregating potential in vivo and vitro, and metastatic potential of KUM·LK-2 were performed under using anti-platelet agent DN 9693 which owned phosphodiesterase blocking activity and not owned anti-cancer activity. DN 9693 blocked platelet aggregating potential and fatal acute thromboembolism of nude mouse induced by KUM·LK-2 cell. KUM·LK-2 metastases were produced subcutaneous implantation group only. But in the case of naturall killer remission using anti-asialo GM1, KUM·LK-2 produce metastases intravenous injection group too. DN 9693 blocked the metastasis of KUM·LK-2 in the case of natural killer reduced nude mouse completely. From these results DN 9693 blocked platelet aggregating activity of KUM·LK-2 cell in vivo and vitro, and blocked metastasis. It was concluded that platelet aggregating activity of KUM·LK-2 cell is necessery to produce metastasis. It was first experiment of human cancer metastasis blocking using anti-platelet agent and proof that anti-platelet agent may usefull for anti-metastasis of human cancer.

Platelet aggregating activity and metastatic remission of human lung adenocarcinoma cell line (KUMLK-2).