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The sialic acid of platelet was determined in Platelet Concentrates during a five day period. Fresh platelet contained 9.49μg sialic acid per mg protein. The content of sialic acid decreased gradually during the storage at 22°C with a final loss of 40% of initial value after five days.The role of sialic acid on several functions of platelet was investigated by neuraminidase treatment. Aggregabilities induced by both ADP and collagen, PF-4 release stimulated by collagen, and adhesiveness to collagen were significantly increased after the treatment under the condition of which a half of sialic acid was removed, whereas hypotonic shock recovery showed a significant diminution. The result suggests that the sialic acid of platelet works in a different manner on each function.

The change of sialic acid in stored platelet and its role in platelet function.