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Serum lipids, pulse wave velocity (PWV) and a2 plasmin inhibitor (a2 PI) of 21 cases with von Willebrand's disease (VWD) were compared with those of normal control subjects. 10 adult VWD patients (average age 40 years) showed significantly lower (p<0. 05-0. 01) serum cholesterol, triglyceride, free cholesterol and free fatty acid levels than the age matched 20 controls. PWV of 70 normal controls was 4. 57+1. 34 m/sec and the correlation coefficient between age and PWV was 0. 297 (p<0.05). Significant difference (p<0.05) was observed in PWV between male (4.72+0.49m/sec) and female (4.40+38m/sec). 12 of the 15 patients with VWD (8-79 years old) had lower value of PWV as compared with the control. a2 PI level of VWD was apparently lower than the control but not significant. Theses results might support the hypothesis of resistarce to arteriosclerosis in patients with von Willebrand's disease.

Studies on serum lipids, pulse wave velocity and 2 plasmin inhibitor in 21 cases with von Willebrand's disease