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For further improvement of the technique to form thrombus in hamster cheek pouch, an arteriole with a diameter of 50-80, um was observed under the microscope and was compressed from lateral side up to 1/5 of the internal diameter by glass capillary with tip of 5, um for 10 min. Simultaneously electrical stimulation (square-wave direct-current, 20 msec in pulse duration, 501zA in pulse strength and 5 Hz) was provided for 80 sec at the beginning of the compression. When the compression with electrical stimulation was repeated 5 to 7 times every 30-50, um along the arteriolar wall, the thrombus was formed 5 X10-cm in height and 150-250 m in length. This thrombus was disaggregated neither spontaneously nor by topical application of PGI2. An electronmicrograph of the thrombus showed that endothelial cells were desquamated and degranulated platelets were adherent to the denuded sites. Topical application of ADP induced the formation of large thrombus so that the arteriolar lumen was nearly obstructed. The superimposed parts of thrombus induced by ADP were disaggregated by topical application of PGI2 dose-dependently.

Further studies on the thrombus formation in hamster cheek pouch