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Fibrinolysis, coagulation, and kinin system relate to pathogenesis of gastric ulcer. Serum kinin has complicated backgrounds and its changes are not in accordance with pathogenesis of gastric ulcer. The relationships between tissue-fibrinolysis and tissue-kallikrein were studied in tissue-plasminogen activator and tissue-kallikrein.Recently, kallikrein has been found in stomach tissue. Synthetic substrate, Prolyl-Phenyl-Arginyl-Naphtyl-Ester, was used to determine its activity. It was studied whether its value reflects clearly tissue-kallikrein or not.Satisfactory results were obtained in the basic study. Then an experiment of stress ulcer due to water immersion was performed with DONRYU rat. In the study on a relationship between tissue-plasminogen activator and tissue-kallikrein during the term from preloading state to the development of ulcer, tissue-kallikrein was reduced and reduction of tissue-plasminogen activator was also observed.

Behavior of rat stomach kallikrein-like substance in experimental gastric ulceration occurrence