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Five patients with chronic adult idiopathic thrombocytopenic purpura (ITP) resistant to standard therapy were treated with pulsed high-dose dexamethasone therapy reported by Andersen (six cycles of dexamethasone, 40mg/day for 4 consecutive days every 28 days). Five female patients were enrolled, median age was 35 years and median platelet count was 18×103/μl at the onset of this treatment. One patient achieved a excellent response with this treatment, but the other four patients were resistant. No serious adverse effects were observed. We conclude that pulsed high-dose dexamethasone therapy had a relatively limited effect in resistant, chronic adult ITP.

Pulsed High-dose Dexamethasone Therapy for Resistant, Chronic Adult Idiopathic Thrombocytopenic Purpura