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The antithrombotic effects of low molecular weight heparin (LMWH) were evaluated in the experimental microvascular thrombosis model using the hamster cheek pouch and were compared to unfractionated heparin (UFH). The platelet-rich thrombus was produced in the venules by the irradiation of the filterd ultraviolet light in combination with the intravascular administration of fluorescein sodium. The antithrombotic activities of these agents were evaluated with respect to the time required for the initiation of thrombus formation (Ti: sec) and the time to stop the blood flow by thrombus (Ts: sec), together with anti-Xa activity (a-Xa: U/ml), anti-IIa activity (a-IIa: U/ml), PT, aPTT and bleeding time (BT: sec) immediately (0), 1 hour (1) and 2 hour (2) after the administration of LMWH or UFH (500 a-XaU/kg).The values of Ti after administration of LMWH or UFH were (0) 122.5±27.8, 114.6±17.5, (1) 97.3±18.9, 87.1±16.8 and (2) 80.1±16.9, 63.2±9.5 (mean±SD) respectively. The values of Ts were (0) 757.2±137.3, 697.7±63.9, (1) 672.1±77.1, 516.1±64.5 and (2) 599.2±47.5, 429.6±54.8, respectively. The levels of a-Xa activity were (0) 0.98±0.05, 0.95±0.03, (1) 0.54±0.08, 0.23±0.12, and (2) 0.24±0.11, 0.08±0.12, respectively. Antithrombotic activity of LMWH was maintained longer than UFH. Significant correlation was found between the antithrombotic activity and a-Xa activity. Moreover, LMWH showed significantly less effect for prolongation of aPTT and BT than UFH.From these results LMWH was suggested to be more beneficial than UFH in clinical use. And this microvascular thrombosis model will contribute to the evaluation of the antithrombotic effects of various agents in vivo.

The Evaluation of Antithrombotic Effects of Low Molecular Weight Heparin in Microvascular Thrombosis