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頸髄損傷者(以下,頸損)8名にメチル硫酸アメジニウム(以下アメジニウム)を投与し,投与前後の起立試験,CVR-R値測定,基礎体力測定,12分間走を行い,起立性低血圧,持久力の改善を観察した.起立試験では,立位負荷時の収縮期圧最低値の有意な上昇と収縮期圧下降度の縮小を認め,基礎体力測定では,%VO2peak・%HRpeakが有意に増加し,12分間走でも,走行距離が有意に延長したが,改善を示さない症例も少数あった.CVR-R値は,一定の変化を認めなかった.以上より,アメジニウムは,大部分の頸損の起立性低血圧,持久力の改善に有効であると考えられた.

Effect of Amezinium Metilsulfate on Orthostatic Hypotension and Physical Fitness in Cervical Cord Injuries.