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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of coronavirus disease 2019 (COVID-19), triggers a pathophysiological process linked not only to viral mechanisms of infectivity, but also to the pattern of host response. Drug repurposing is a promising strategy for rapid identification of treatments for SARS-CoV-2 infection, and several attractive molecular viral targets can be exploited. Among those, 3CL protease is a potential target of great interest.

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Screening Anti-inflammatory, Anticoagulant, and Respiratory Agents for SARS-CoV-2 3CL&lt;sup&gt;pro&lt;/sup&gt; Inhibition from Chemical Fingerprints Through a Deep Learning Approach