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Nowadays, depression is a serious clinical problem, as the prevalence of its various forms increases and there are growing numbers of patients with severe forms of depression and treatment-refractory depression. Depressed patients have been observed to have decreased levels of kynurenic acid (KYNA), which is the only endogenous antagonist of ionotropic N-methyl-D-aspartate (NMDA) receptors. The aim of this study was to identify subgroups of patients differing in the dynamics of changes in KYNA concentration during electroconvulsive therapy (ECT).

psychiatria danubina

DIFFERENCES IN THE DYNAMICS OF CHANGES IN THE CONCENTRATION OF KYNURENIC ACID IN THE BLOOD SERUM OF DEPRESSED PATIENTS TREATED WITH ELECTROCONVULSIVE THERAPY