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Hemoglobin adducts have been suggested to have the same life span as hemoglobins (half-life in man : 60 days) and are a potential biological exposure index with a longer life span than metabolites in blood and urine.1) Using ICR mice, we have already investigated the effectiveness of hemoglobin adducts as a biological index of exposure to methyl bromide (MB).2,3) In the present report we determined hemoglobin adducts in MB workers and examined their effectiveness as a biological index of exposure to MB.

Biological exposure monitoring of methyl bromide workers by determination of hemoglobin adducts.