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gram of creatinine2) has been widely used for urinary biological monitoring.1) Previously, we established methods for the determination of concentrations of urinary metabolites of organic solvents by HPLC.3-10) An attempt was made in the present study to determine the concentrations of urinary metabolites and creatinine simultaneously by HPLC. Hippuric acid (HA), o-, mand p-methylhippuric acids (MHAs), and mandelic acid (MA) were obtained from Tokyo Kasei Co., Tokyo, and creatinine was

Simultaneous determination of urinary creatinine and metabolites of aromatic organic solvents by automated high performance liquid chromatography.