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possibly involved in the regulation of sleep. The present study was designed to investigate the role of brain monoamines in the sleep disorder of MMC-dosed rats and attempts to elucidate the MMC-induced sleep disorder from the standpoint of changes in the concentrations of brain monoamines. MMC was administered orally to 12 Sprague-Dawley male rats 8 weeks age at a dose of 15 mg MMC/kg body weight/day for two consecutive days. Twelve rats served as a control group and received vehicle administration of sesame seed oil. On the 17th day after the first MMC dose, 12 rats (6 each from the experimental and the control groups) were decapitated in the morning (10:00-11:00) and the other 12 at night (23:00-24:00). The brain of each rat was removed

Neurochemical correlates of sleep disorder of rats administered with methylmercury chloride.