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MATERIALS AND METHODS Chromium is known to be an essential element1. Epidemiological and experimental studies have, however, demonstrated that some chromium compouds (mainly hexavalent salts) are mutagenic carcinogens2-5) (see ref. 1 for review). Recent studies have also shown that the hexavalent compounds induce dose-related increases in chromosomal aberrations and sister chromatid exchanges in cultured human lymphocytes and mammalian cells exposed to the compounds6-10). In the present study, we examined by dosage fractionation whether the hexavalent compound, chromiunm trioxide, inhibits the repair of radiation-induced chromosome breaks.

Inhibition of repair of radiation-induced chromosome breaks: Effects of chromium trioxide on cultured human lymphocytes.