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The apatite cement bulk powder consisting of an equimolarmixture of tetracalcium phosphate (TECP, Ca4(PO4)2O),dicalcium phosphate dihydrate (DCPD, CaHPO4 2H2O) wasprepared by grinding at 90 strokes per second for 10 min in anagate vibration mixer. The 0.5% b-estradiol (ES)-loaded apatitecement obtained from the mixed powder of TECP and DCPD andES after storing at 37°C and 100% relative humidity.

Bone Regeneration by Using Drug Delivery System Technology and Apatite Intelligent Materials