English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Histomorphometric analyses of the mandible and femur were performed in senescence-accelerated mice (SAM) using SAMP6 as a senile osteoporosis (OP) model, SAMP8 as a temporomandibular joint osteoarthritis (TMJOA) model, and SAMR1 as control. Thirty-six male mice at 2 or 4 months of age (6 for each strain and age) were used. The cortical thickness index (CTI), bone area (B.Ar/T.Ar), trabecular width (Tb.Wi), trabecular number (Tb.N), trabecular separation (Tb.Sp), osteoblast perimeter (N.Ob/B.Pm), and osteoclast perimeter (N.Oc/B.Pm) were assessed in the distal femoral metaphysis and in the mandibular ramus including the alveolar bone. Compared with SAMR1, SAMP6 showed lower B.Ar/T.Ar and Tb.Wi in the femur and mandible at 2 and 4 months of age. This strain showed lower CTI in both bones and higher Tb.N and Tb.Sp in the femur at 4 months of age. SAMP8 showed higher CTI in both bones at 2 months of age and maintained a high index in the mandible but not in the femur at 4 months of age; however trabecular bone mass was not reduced. SAMP6 exhibited lower N.Ob/B.Pm in the femur but not in the mandible at 4 months of age, while SAMP8 showed lower N.Oc/B.Pm in the mandible but not in the femur at 2 and 4 months of age. The differential histomorphometric features of the mandible in different SAM strains may imply a difference in mandibular bone property between SAM mice with senile OP and TMJOA genetic background.

journal of hard tissue biology

Differential bone histomorphometric characters of the mandible in senescence-accelerated mice (SAMP6 and SAMP8): murine models for senile osteoporosis and temporomandibular joint osteoarthritis