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Candida albicans is the main cause of candidiasis in Indonesia. Cases of infection due to the fungus C. albicans have increased globally. Treatment of diseases caused by fungal infections has been widely carried out using synthetic antifungals. The use of synthetic antifungals has limitations, such as severe side effects, narrow spectrum of antifungals, poor penetration of certain tissues and the emergence of resistant fungi. One alternative that can be done is to use plants as natural anti-fungi. The efficacy of medicinal plants is generally caused by the activity of secondary metabolite compounds produced from plants. Saponin is a secondary metabolite compound that functions as an anti-fungal. Frangipani flower has medicinal properties, the effectiveness of antifungal saponins in white frangipani flowers is rarely Metamorfosa:Journal of Biological Sciences 8(1): 74-80 (Maret 2021) eISSN: 2655-8122 75 reported. The purpose of this study was to determine the saponin content of white frangipani flowers (Plumeria acuminata) and the effectiveness of these compounds in the growth of C. albicans. The method used in this study: identification of saponin antifungal compounds was carried out by foam testing. The antifungal effectiveness test of saponin compounds on the growth of C. albicans was tested by the KirbyBauer method. Quantitative data on the diameter of the inhibition zone formed in each treatment were analyzed using ANOVA (Analysis of Variance) at 5% level. The results of ANOVA analysis were significantly different (P <0.05) followed by the Duncan test to see the differences between treatments. The results showed that saponins of white frangipani (P. acuminata) had antifungal activity in C. albicans which was indicated by the formation of an inhibition zone of 7.7 mm (moderate category) so that it could be used as a natural anti-fungal. Keyword: Candida albicans, Acacia auriculiformis, antifungal, saponin

Aktivitas Antifungi Saponin Bunga Kamboja Putih (Plumeria acuminata) pada Candida albicans ATCC 10231