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Klebsiella pneumoniae, one of hospital associated infections agents, become more prevalence in worldwide. It is an opportunistic&#x0D;pathogen that can cause wide spectrum of diseases such as pneumonia and sepsis. Capability of this bacterium in causing&#x0D;diseases is influenced by its virulence factors. Capsule (K) is considered as the major virulence factor responsible in avoiding&#x0D;first defense mechanism of host cells. Almost no study about molecular characterization of capsule is reported in Bali; therefore,&#x0D;this study is aimed to determine the capsular genotype of  K. pneumoniae isolated from clinical specimens at Sanglah General&#x0D;Hospital. Samples were collected between January until Desember 2013 in Sanglah General Hospital at Clinical Microbiology&#x0D;Laboratory. Total of 56 samples were examined taken from blood, urine, pus, sputum, and other sources. All  K. pneumoniae&#x0D;DNA were then subjected to PCR using specific primer pairs against K1, K2 and K5. The results showed that from 56  K.&#x0D;pneumoniae clinical isolates only 12 (21.4%) were PCR positive, and all (100%) of them were positive for K2 capsule gene. Ten&#x0D;(83.3) of them were from blood, 1 (8.3%) from sputum, and 1 (8.3%) from other specimens. Finding of K2 capsule gene in most&#x0D;K. pneumoniae clinical isolates at Clinical Microbiology Laboratory in Sanglah General Hospital might figure out the&#x0D;relationship of capsular type with severity of diseases. However, further study of capsule in Bali with higher isolates number will&#x0D;help in understanding of pathogenicity of K2 capsule in order to treat the infections itself.

CAPSULAR GENOTYPING OF Klebsiella pneumoniae ISOLATED FROM CLINICAL SAMPLES AT SANGLAH GENERAL HOSPITAL IN 2013