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This study aimed to determine the antipyretic effect of ethanol extract of Nephelium lappaceum fruit peel and to determine its total phenol content. In vivo antipyretic activity test was conducted on Wistar male rats induced with yeast and applying Folin-Coicalteu method for determining the total phenol content of the extract. The tests result showed an antipyretic activity with the application of the extracts at the doses of 5 mg/100 g BW; 10 mg/100 g BW, and 20 mg/100 g BW indicated by a reduction of rectal temperature of the rats compared to the negative control and the sharp reducing temperature was observed after 210 minutes of oral administration of the extract. Phytochemical screening results indicated the presence of phenol, tannin, flavonoid, saponin and terpenoid, with phenolic compound predominantly. The total phenol content of ethanol extract of Nephelium lappaceum fruit peel was 39.7861g GAE/100 g or 39.78%.

AKTIVITAS ANTIPIRETIK EKSTRAK ETANOL KULIT BUAH RAMBUTAN (Nephelium lappaceum L) SECARA IN VIVO DAN KANDUNGAN FENOLIK TOTALNYA